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Symbol Name ID |
L2hgdh
L-2-hydroxyglutarate dehydrogenase MGI:2384968 |
| Darker colors indicate more annotations |
| Human Phenotypes | Infectious encephalitis |
Spastic tetraparesis |
Gliosis |
Severe demyelination of the white matter |
Corpus callosum atrophy |
Leukoencephalopathy |
Aplasia/Hypoplasia of the cerebellum |
Cerebellar atrophy |
Global brain atrophy |
Abnormal pyramidal tract morphology |
Neoplasm of the nervous system |
Ataxia |
Abnormality of extrapyramidal motor function |
Abnormal pyramidal sign |
Aphasia |
Atypical behavior |
Intellectual disability |
Intellectual disability, progressive |
Intellectual disability, severe |
Developmental regression |
Seizure |
| Disease(s) Associated with L2HGDH | |||||||||||||||||||||
| L-2-hydroxyglutaric aciduria |
| Mouse Phenotypes | increased susceptibility to pharmacologically induced seizures |
abnormal brain morphology |
abnormal glial cell morphology |
abnormal oligodendrocyte morphology |
abnormal myelin sheath morphology |
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| Availability | Mouse Genotype | |||||
| L2hgdhGt(DC0625)Wtsi/L2hgdhGt(DC0625)Wtsi | ||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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